Resistance to Antibiotics: The Good, the Bad and the Ugly

Antimicrobial drugs play a critical role in the treatment of diseases, their use is essential to protect both human and animal health. However, antimicrobials are often misused for treatment and prevention of diseases in livestock sector, aquaculture as well as crop production. Credit: FAOBy Baher KamalROME, Dec 6 2017 (IPS)The growing resistance to antibiotics and other antimicrobials due to their overuse and misuse both in humans and animals has become an alarming global threat to public health, food safety and security, causing the deaths of 700,000 people each year. This is a fact. The good news is that now more and more countries have adopted measures to prevent the excessive and wrong use of antimicrobials. The bad ones are that these drugs continue to be intensively utilised to accelerate the growth of animals, often for the sake of obtaining greater commercial benefits.According to the first annual survey conducted by the Food and Agriculture Organization of the UN (FAO), the World Health Organization (WHO), and a global intergovernmental body on animal health—the World Organisation for Animal Health (OIE), more than 6.5 billion people – over 90 per cent of the world’s population – now live in country that has in place, or is developing, a national action plan on antimicrobial resistance (AMR).“Nearly all of these plans cover both human and animal health in line with the recommended ‘one health‘ multi-sectoral approach,”...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Editors' Choice Environment Featured Food & Agriculture Global Headlines Health Humanitarian Emergencies IPS UN: Inside the Glasshouse Poverty & SDGs Projects Regional Categories TerraViva United Nations Improving the lives of ru Source Type: news

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In this study, yellowfin seabream (Acanthopagrus latus), a euryhaline marine teleost, was used to investigate immune responses of different tissues (gill, liver, and muscle) under hypoosmotic stress. Comparative transcriptomic and physiological analyses of three tissues were conducted after fish exposed to the fresh water (FW, salinity = 0 ppt), low-saline water (LW, salinity = 3 ppt), and brackish water (BW, salinity = 6 ppt) for 8 days. The results showed that hypoosmotic stress dramatically altered the gene expression of three tissues in yellowfin seabream; The investigation of differentially expressed...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
In this study, UV photolysis was selected as an appropriate pretreatment technology for antibiotic-containing wastewater. It could decompose many kinds of antibiotics and was not inhibited by the coexisting organics in wastewater. The antibacterial activities of five kinds of antibiotics, which were eliminated with UV irradiation, exhibited a significantly positive correlation with their parent compound concentrations. The photodecomposition of the main functional groups in antibiotics contributed to the elimination of antibacterial activity. Defluorination was the main pathway to eliminate the antibacterial activity of an...
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
In this study, the Cyprinus carpio intoxication model was used to compare the differences in intoxication effect of alcoholic beverages and to assess the impacts of huangjiu components on intoxication for the first time. Exposure to huangjiu led to the most rapid physical imbalance of C. carpio, followed by red wine and Western liquor. Higher alcohols, biogenic amines and aldehydes could cause physical imbalance of fish by themselves, and synergistic effects were observed when combined with ethanol. 2-Phenylethanoland and isopentanol had the greatest positive effect on huangjiu intoxication, followed by histamine and phene...
Source: Food Chemistry - Category: Food Science Source Type: research
We present the current portfolio of next-generation anti-Wolbachia candidates discovered through phenotypic screening of chemical libraries and validated in a range of in vitro and in vivo filarial infection models. Several novel chemotypes have been identified with selected narrow-spectrum anti-Wolbachia specificity and superior time-to-kill kinetics compared with doxycycline. We discuss the opportunities of developing these novel anti-Wolbachia agents as either cures, adjunct therapies or new preventatives for the treatment of veterinary filariasis.
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
Raquel Ferrer-Espada1,2, Xiaojing Liu1,2, Xueping Sharon Goh1,2 and Tianhong Dai1,2* 1Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States 2Vaccine &Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States Polymicrobial biofilms, in which mixed microbial species are present, play a significant role in persistent infections. Furthermore, polymicrobial biofilms promote antibiotic resistance by allowing interspecies transfer of antibiotic resistance genes. In the present study, we investigated the effec...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
(CNN) — From climate change to superbugs, the World Health Organization has laid out 10 big threats to our global health in 2019. And unless these threats get addressed, millions of lives will be in jeopardy. Here’s a snapshot of 10 urgent health issues, according to the United Nations’ public health agency: Not vaccinating when you can One of the most controversial recent health topics in the US is now an international concern. “Vaccine hesitancy — the reluctance or refusal to vaccinate despite the availability of vaccines — threatens to reverse progress made in tackling vaccine-prevent...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Local TV Source Type: news
Author Affiliations open 1Public Health Institute, Oakland, California, USA 2Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA 3Instituto de Microbiologia, Colegio de Ciencias Biologicas y Ambientales, Universidad San Francisco de Quito, Quito, Ecuador 4Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan, USA 5Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA 6Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, USA PDF Version (176 KB) Abstract ...
Source: EHP Research - Category: Environmental Health Authors: Tags: Brief Communication Source Type: research
Posters: Misuse of antibiotics and risks. Credit: WHOBy Baher KamalROME, Oct 4 2017 (IPS)The world is running out of new antibiotics to combat the growing threat of antimicrobial resistance, a new specialised report warns ahead of this year’s World Antibiotic Awareness Week, adding that most of the drugs currently in the clinical pipeline are modifications of existing classes of antibiotics and are only short-term solutions. The latest World Health Organization (WHO) report on this issue “Antibacterial agents in clinical development – an analysis of the antibacterial clinical development pipeline, includi...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Featured Global Headlines Health Human Rights TerraViva United Nations Source Type: news
Since the introduction of penicillin in the middle of the 20th century, antimicrobial treatments have been used not only in human medicine but in veterinary care as well. But their excessive use in livestock (and aquaculture) contaminates the environment and contributes to a rise of resistant microorganisms, posing threats to human health, animal health, food security and people’s livelihoods. Photo: FAOBy Baher KamalROME, Jan 11 2017 (IPS)There is a major though silent global threat to human and animal health, with implications for both food safety and food security and the economic well-being of millions of farming...
Source: IPS Inter Press Service - Health - Category: Global & Universal Authors: Tags: Featured Food & Agriculture Global Headlines Health Human Rights Projects TerraViva United Nations Improving the lives of rural populations: better nutrition & agriculture productivity Source Type: news
By Kate Kelland LONDON, April 29 (Reuters) - Only 34 countries have national plans to fight the global threat of antibiotic resistance, meaning few are prepared to tackle "superbug" infections which put even basic healthcare at risk, the WHO said on Wednesday. In a survey of government plans to tackle the issue, the World Health Organization said only a quarter of the 133 countries that responded were addressing the problem. "This is the single greatest challenge in infectious diseases today," said Keiji Fukuda, the WHO's assistant director-general for health security. "All typ...
Source: Science - The Huffington Post - Category: Science Source Type: news
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