Adhering to the principles of clinical pharmacology - The Correct Fixed Combinations of Antihypertensive Drugs.

Adhering to the principles of clinical pharmacology - The Correct Fixed Combinations of Antihypertensive Drugs. Expert Rev Clin Pharmacol. 2017 Dec 01;: Authors: Paulina L, Elzbieta M, Anna TK, Banach M, Jolanta M Abstract Introduction Hypertension is one of the primary modifiable risk factors for cardiac and renal diseases. The prevalence of hypertension appears to be around 30-45% of the general population, with a steep increase with ageing. The administration of blood pressure-lowering drugs is to reduce the risk of major clinical cardiovascular outcomes: stroke, myocardial infarction, heart failure and cardiovascular deaths. Hypertension guidelines recommend combination therapy in patients with high cardiovascular risk and with subclinical organ damage as well as when monotherapy fails. Areas covered As the etiology of essential hypertension is multifactorial, combination therapy using different classes of antihypertensive agents have greater effect than each on its own (synergistic effect), may have better tolerability (two components minimizing each other's side effects) and lead to improved patient compliance. Several studies assess the hypotensive efficacy on drug combination, there are also studies n triple drug combination. Expert commentary At present, dual and triple combination therapy is available to hypertensive patients with good clinical outcomes, compliance and low profile of side effects. Hypertensive patients usua...
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Tags: Expert Rev Clin Pharmacol Source Type: research