Reproductive factors, nutritional status and serum 25(OH)D levels in women with breast cancer: A case control study

Publication date: Available online 11 November 2017 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Nighat Y. Sofi, Monika Jain, Umesh Kapil, Vuthaluru Seenu, Lakshmy R., Chander P. Yadav, Ravindra M. Pandey, Neha Sareen The study was conducted with an objective to investigate the association between reproductive factors, nutritional status and serum 25(OH)D levels among women diagnosed with breast cancer (BC). A total of 200 women with BC attending a tertiary healthcare institute of Delhi, India matched with 200 healthy women for age (±2years) and socio economic status were included in the study. Data was collected on socio-demographic profile, reproductive factors, physical activity and dietary intake (24hour dietary recall and food frequency questionnaire) using interviewer administered structured questionnaires and standard tools. Non fasting blood samples (5ml) were collected for the biochemical estimation of serum 25(OH)D and calcium levels by chemiluminescent immunoassay and colorimetric assay technique. Data was analyzed by univariable conditional logistic regression and significant variables with (p< 0.05), were analyzed in final model by conditional multivariable logistic regression analysis. The mean age of patients at diagnosis of BC was 45±10years. Results of multivariable conditional logistic regression analysis revealed significantly higher odds of BC for reproductive factors like age at marriage (more than 23 year...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research