Spontaneous Neuronal Network Persistent Activity in the Neocortex: A(n) (Endo)phenotype of Brain (Patho)physiology.

In this study we introduce the novel idea that recurring persistent network activity (Up states) in the neocortex at the reduced level of the brain slice may be used as an endophenotype of brain disorders that will help us understand not only how local microcircuits of the cortex may be affected in brain diseases, but also when, since an important issue for the design of successful treatment strategies concerns the time window available for intervention. PMID: 28971403 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research