The anti-cancer properties in parallel with toxic effects of indole-3-carbinol derivatives.

The anti-cancer properties in parallel with toxic effects of indole-3-carbinol derivatives. Immunol Lett. 2017 Aug 26;: Authors: Karimabad MN, Falahati-Pour SK, Hassanshahi G, Koochakzadeh L Abstract The Indole-3-carbinol (I3C) is produced by the members of the cruciferous family, in particular members of the Brassica genus. In vitro investigations has shown that I3C suppresses the proliferation of various tumor cells, including breast, prostate, endometrial, colon cancers and leukemic cells via induction of G1/S arrest of the cell cycle and further induces apoptosis. Cancer cells exhibit deregulation in multiple cellular signaling pathways. Therefore, treatments with specific agents which only target one of these pathways are usually not effective in cancer therapy. Combination therapy with chemotherapeutic agents by distinct molecular mechanisms is considered as a promising method with higher efficacy; however, employing multiple agents is accompanied by additional toxicity. Accumulating evidences demonstrated that that I3C as a natural product has growth inhibitory and apoptosis inducing effects on human and animal cancer cells mediated by targeting multiple cellular signaling pathways in vitro without causing unwanted toxic effects on normal cells. Thus, these non-toxic "natural products" from natural resources could be beneficial in combination with conventional chemotherapeutic agents for the treatment of human malignancies wit...
Source: Immunology Letters - Category: Allergy & Immunology Authors: Tags: Immunol Lett Source Type: research