At the Cusp of Solving Cognitive Aging?

  It’s Brain Awareness Week, and we’ll be hearing about breakthroughs in basic science that could lead to big advances in how we live. Yet, most of the discoveries will require decades of further work, before they help people. But, what if we had a time machine and could travel ahead to see which of these discoveries actually becomes important in our lives? Well, we don’t have a time machine, but the two of us do have decades of experience in turning basic science discoveries into products that change lives.  We want to tell you about that journey — from what we discovered in basic research decades ago to how it now impacts the lives of millions. Our story began with a basic science inquiry: Can brain training improve cognitive skills in a manner that impacts real world function and changes the trajectory of aging? I (Karlene Ball) was one of the organizers of an NIH-funded randomized controlled trial, called the ACTIVE Study. ACTIVE looked at three different theories about what is most important for successful cognitive aging — memory (which is the most often-cited concern about cognitive aging), reasoning (which helps us continue to function independently as we age) or speed of processing (which is fundamental to receiving and acting on information and which slows with each passing decade). We enrolled about 3,000 older (aged 65+) people, and divided them into a control group and three training groups: (1) memory training – a cl...
Source: On the Brain by Dr. Michael Merzenich, Ph.D. - Category: Neuroscience Authors: Tags: Aging and the Brain Brain Plasticity BrainHQ Source Type: blogs

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ConclusionIn a large group of older persons with dementia resident in nursing homes, a low daily consumption of caffeine was associated with greater behavioral symptoms.
Source: The Journal of Nutrition, Health and Aging - Category: Nutrition Source Type: research
INTRODUCTION Unintentional and intentional (e.g., suicide) injury and death are risks among individuals with cognitive impairment. Firearm access is a particular concern for individuals with Alzheimer╩╝s disease and related dementias (ADRD), given firea...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
CONCLUSION: Depressive symptomatology is associated with cognitive deterioration. Depression is prevalent in institutions that care for older, more dependent adults. PMID: 32634807 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
This study investigated caregiver outcomes when a psychoeducation program for older people with dementia and caregivers is modified to extend practice in memory strategies. Moderation effects of increased memory strategy use were also explored. Fifty-six care dyads participated in the multicenter, randomized controlled trial comparing psychoeducation (active control) with psychoeducation and memory strategy practice (intervention). Primary outcome was memory strategy use; secondary outcome was caregiver emotional reactivity (burden, depression, and anxiety). Results showed memory strategy use significantly increased follow...
Source: International Journal of Aging and Human Development - Category: Geriatrics Tags: Int J Aging Hum Dev Source Type: research
This study aimed to identify and compare the correlates of sleep disturbance in older adults with MCI and those in cognitively healthy older adults. A comparative cross-sectional study was adopted. Data were obtained from 219 Chinese community-dwelling older adults (female: 70.3%), which consisted of 127 older adults with MCI and 92 age-matched cognitively healthy controls. The candidate correlates of sleep disturbance included socio-demographic correlates, health-related factors, lifestyle-related factors and psychological factor. Descriptive, correlational and regression statistics were used for data analysis. The preval...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Authors: Tünel M, Çakmak S, Tamam L, Demir T Abstract Normal pressure hydrocephalus (NPH), typically associated with the triad of gait disturbance, dementia and urinary incontinence, rarely presents with symptoms of mania, depression or psychosis and psychiatric disorders may complicate the diagnosis. Few cases of NPH and psychiatric disease comorbidity have been reported so far. In most of these cases, NPH was associated with depression and psychotic symptoms. Mania symptoms were also reported in a few cases those of which were associated with a history of bipolar disorder (BPD) or subthreshold BPD sym...
Source: Turk Psikiyatri Dergisi - Category: Psychiatry Tags: Turk Psikiyatri Derg Source Type: research
CONCLUSIONS: These findings indicate that less use of pronouns that refer to the couple (we-pronouns used by either partner) and greater use of pronouns that refer to the PWD (I-pronouns used by the PWD) are indicative of caregivers at heightened risk for lower well-being. PMID: 32610328 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
DISCUSSION AND IMPLICATIONS: Despite the relatively harmonious relationships among family-staff in ALFs, sources of conflict and negative interactions were identified, revealing the importance of collaborative relationships and the influence these relationships have on both family and staff outcomes. These findings can inform intervention efforts to improve family-staff interactions within ALFs. PMID: 32614048 [PubMed - as supplied by publisher]
Source: The Gerontologist - Category: Geriatrics Authors: Tags: Gerontologist Source Type: research
CONCLUSION: Implications for PATH included a focus on facilitating open communication, supporting the continuation of valued roles, and improving confidence. PMID: 32600788 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
To evaluate the role of cortical amyloid deposition as a factor contributing to memory dysfunction and increased risk of dementia associated with late life depression (LLD).
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Archival Report Source Type: research
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