The potential regulatory mechanisms of the gonadotropin-releasing hormone in gonadotropin transcriptions identified with bioinformatics analyses.

CONCLUSIONS: The present study revealed the involvement of GnRH in the regulation of gonadotropin biosynthesis and metabolism in the maintenance of reproduction, achieved by bioinformatics analyses. This, indicates that the GnRH signalling pathway played a central linkings role in reproductive function and metabolic balance. In addition, the present study identified the difference response between GnRH pulse and GnRH tone, indicated that abnormal GnRH pulse and amplitude may cause disease, which may provide an improved understanding of the GnRH pathway and a new insight for disease diagnosis and treatment.
PMID: 28623929 [PubMed - in process]

Source: Reproductive Biology - June 17, 2017 Category: Reproduction Medicine Authors: Xiang W, Zhang B, Lv F, Feng G, Chen L, Yang F, Zhang K, Cao C, Wang P, Chu M Tags: Reprod Biol Endocrinol Source Type: research