TRAF3/CYLD mutations identify a distinct subset of human papilloma virus ‐associated head and neck squamous cell carcinoma
CONCLUSIONSDefects in TRAF3/CYLD were accompanied with the activation of nuclear factor κB signaling and maintenance of episomal HPV in tumors, suggesting that these mutations may support an alternative mechanism of HPV tumorigenesis in head and neck tumors. See editorial on pages 000‐000, this issue. Cancer 2017. © 2017 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society.
Source: Cancer - Category: Cancer & Oncology Authors: Michael Hajek, Andrew Sewell, Susan Kaech, Barbara Burtness, Wendell G. Yarbrough, Natalia Issaeva Tags: Original Article Source Type: research
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