Assessment of Tryptophan Uptake and Kinetics Using 1-(2-18F-Fluoroethyl)-L-Tryptophan and {alpha}-11C-Methyl-L-Tryptophan PET Imaging in Mice Implanted with Patient-Derived Brain Tumor Xenografts

Conclusion: 18F-FETrp tumoral uptake, biodistribution, and radiation dosimetry data provide strong preclinical evidence that this new radiotracer warrants further studies that may lead to a broadly applicable molecular imaging tool to examine abnormal tryptophan metabolism in human tumors.

Source: Journal of Nuclear Medicine - January 31, 2017 Category: Nuclear Medicine Authors: Michelhaugh, S. K., Muzik, O., Guastella, A. R., Klinger, N. V., Polin, L. A., Cai, H., Xin, Y., Mangner, T. J., Zhang, S., Juhasz, C., Mittal, S. Tags: Basic Source Type: research