Ncog-12. neurocognition in low-grade gliomas: associations with measurable and perceived impairments

In this study, 31 subjects with low-grade glioma underwent neurocognitive testing using a computerized program that assessed neurocognitive domains of cognitive flexibility, complex attention, executive functioning, psychomotor speed, processing speed, reaction time, verbal and visual memory. These measures and two HRQoL measures, the Functional Assessment of Cancer Therapy-Brain (FACT-Br) and Functional Assessment of Cancer Therapy-Cognition Function (FACT-Cog), were completed at baseline and 6 months later. Of the 31 subjects enrolled, majority were male (N=18, 58.1%), had ≥ 16 years of education (N=18, 58.1%), had KPS ≥90 (N=21, 67.7%), and had gross total resection (N=21, 67.7%). Only 4 subjects had prior radiation therapy, and 35.5% had prior chemotherapy. For all neurocognitive domains, there was no significant change in test scores over the 6 month period and a majority performed well with only 16.1-45.2% having standardized neurocognitive scores more than one standard deviation below the mean. Spearman’s rank correlation coefficients indicated perceived cognitive impairment, as measured by FACT-Cog, was significantly correlated with performance on domains of psychomotor speed (p=0.0049), complex attention (p=0.0059), cognitive flexibility (p=0.0133), and executive functioning (p=0.0279). Memory domains and reaction time did not correlate with perceived cognition on FACT-Cog. Less perceived cognitive impairment in low-grade glioma patients is...

Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Peters, K., Affronti, M. L., Woodring, S., Minchew, J., Lipp, E., McSherry, F., Herndon, J., Randazzo, D., Desjardins, A., Vlahovic, G., Friedman, H., Barboriak, D. Tags: NEURO-COGNITIVE OUTCOMES Source Type: research