Cardiac sympatho-vagal balance and ventricular arrhythmia
A hallmark of cardiovascular disease is cardiac autonomic dysregulation. The phenotype of impaired parasympathetic responsiveness and sympathetic hyperactivity in experimental animal models is also well documented in large scale human studies in the setting of heart failure and myocardial infarction, and is predictive of morbidity and mortality. Despite advances in emergency revascularisation strategies for myocardial infarction, device therapy for heart failure and secondary prevention pharmacotherapies, mortality from malignant ventricular arrhythmia remains high.
Conclusions: Approximately, one-fourth of patients developed hyperkalaemia during follow-up which was associated with a lower MRA dose during follow-up. Discontinuation of MRA, but not hyperkalaemia itself, was associated with an increased risk of all-cause mortality and heart failure admission in HFrEF patients. PMID: 32264757 [PubMed - as supplied by publisher]
Background: Even with antiretroviral therapy (ART), persons with HIV (PWH) experience increased morbidity and mortality. Cytomegalovirus (CMV) and Epstein--Barr virus (EBV) co-infections likely exacerbate inflammatory-related diseases. Objective: To determine if presence of detectable CMV or EBV DNA in peripheral blood mononuclear cells (PBMC) is associated with non-AIDS events among PWH receiving modern ART. Design: We performed a case--control study of PWH starting ART and HIV-suppressed at year 1 and thereafter, 140 cases who experienced non-AIDS events and 305 matched controls. Events included myocardial infarc...
Conclusion: ART may reduce the risk of NCIs in HIV-infected patients in general. Further research to investigate NCIs on specific antiretroviral regimens and comorbidities may provide insights regarding the long-term clinical care of these patients.
In this study, we hypothesised that elevated serum TN-C at enrolment in participants with type 2 diabetes would be associated with increased risk of death and major adverse CV events (MACE) during follow-up.MethodsWe used a prospective, monocentric cohort of consecutive type 2 diabetes participants (the SURDIAGENE [SUivi R énal, DIAbète de type 2 et GENEtique] cohort) with all-cause death as a primary endpoint and MACE (CV death, non-fatal myocardial infarction or stroke) as a secondary endpoint. We used a proportional hazard model after adjustment for traditional risk factors and the relative integrated disc...
Conclusions/interpretationIn two prospective, community-based studies, elevated levels of GIP were associated with greater risk of all-cause and cardiovascular mortality within 5 –9 years of follow-up, whereas GLP-1 levels were not associated with excess risk. Further studies are warranted to determine the cardiovascular effects of GIP per se.
Conclusions/interpretationOur study provides the first evidence thatAkap1 deficiency exacerbates diabetic cardiomyopathy by impeding mitochondrial translocation of NDUFS1 to induce mitochondrial dysfunction and cardiomyocyte apoptosis. Our findings suggest thatAkap1 upregulation has therapeutic potential for myocardial injury in individuals with diabetes.
Publication date: Available online 8 April 2020Source: Journal of EthnopharmacologyAuthor(s): Shuai Mao, Wenwei Ouyang, Yuanshen Zhou, Ruixiang Zeng, Xujie Zhao, Qubo Chen, Minzhou Zhang, Aleksander Hinek
Publication date: Available online 8 April 2020Source: JACC: Heart FailureAuthor(s): Sebhat Erqou, Lan Jiang, Gaurav Choudhary, Michelle Lally, Gerald S. Bloomfield, Andrew R. Zullo, Theresa I. Shireman, Mathew Freiberg, Amy C. Justice, James Rudolph, Nina Lin, Wen-Chih Wu
Publication date: Available online 8 April 2020Source: JACC: Heart FailureAuthor(s): Douglas L. Mann
Publication date: Available online 8 April 2020Source: JACC: Heart FailureAuthor(s): Sameer Prasada, Adovich Rivera, Arvind Nishtala, Anna E. Pawlowski, Arjun Sinha, Joshua D. Bundy, Simran A. Chadha, Faraz S. Ahmad, Sadiya S. Khan, Chad Achenbach, Frank J. Palella, Rosalind Ramsey-Goldman, Yvonne C. Lee, Jonathan I. Silverberg, Babafemi O. Taiwo, Sanjiv J. Shah, Donald M. Lloyd-Jones, Matthew J. Feinstein