Nanoparticle-Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia-Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction [Coronary Heart Disease]

Conclusions
Mdivi1-NP treatment reduced IR injury through inhibition of MOMP, even in the absence of a CypD/MPTP opening. Thus, nanoparticle-mediated drug delivery of Mdivi1 may be a novel treatment strategy for IR injury.

Source: JAHA:Journal of the American Heart Association - July 21, 2016 Category: Cardiology Authors: Ishikita, A., Matoba, T., Ikeda, G., Koga, J.-i., Mao, Y., Nakano, K., Takeuchi, O., Sadoshima, J., Egashira, K. Tags: Basic Science Research, Myocardial Infarction Coronary Heart Disease Source Type: research