Prophylactic Gynecologic Specimens from Hereditary Cancer Carriers.

Prophylactic Gynecologic Specimens from Hereditary Cancer Carriers. Surg Pathol Clin. 2016 Jun;9(2):307-28 Authors: Shaw PA, Clarke BA Abstract Hereditary breast ovarian cancer and Lynch/hereditary nonpolyposis colorectal cancer syndrome account for most hereditary gynecologic cancers. In the absence of effective cancer screening and other preventative strategies, risk-reducing surgery in women who are known to be at genetic risk of BRCA-associated or of Lynch syndrome carcinomas is effective in significantly decreasing the lifetime risk of developing malignancy. Reflex genomic testing of high-grade ovarian cancers and reflex immunohistochemistry in endometrial cancers will lead to greater recognition of germline-associated cancers. Approaches to processing surgical specimens, the recognition and classification of cancer precursor lesions, and differentiation from their mimics are discussed. PMID: 27241111 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/27241111?dopt=Abstract

Source: Clinical Colorectal Cancer - May 31, 2016 Category: Cancer & Oncology Authors: Shaw PA, Clarke BA Tags: Surg Pathol Clin Source Type: research