Innate Immune Mechanism for Viral dsRNA Detection – RIG-I-like Receptors
Immunology Interest Group Dr. Hur received her B.S. in physics from Ewha Women’s University in Korea in 2001, her Ph.D. in physical chemistry with Dr. Thomas C. Bruice at the University of California, Santa Barbara in 2003 and then did her post-doctoral work in X-ray crystallography with Dr. Robert M. Stroud at the University of California, San Francisco. Dr. Hur joined Harvard Medical School in 2008 as an assistant professor in the Department of Biological Chemistry and Molecular Pharmacology. In 2014, she was promoted to an associate professor with a joint appointment at Boston Children’s Hospital. Dr. Hur is a recipient of the 2009 Massachusetts Life Sciences Young Investigator Award, the 2010 Pew Scholar Award, the 2015 Vilcek Prize for Creative Promise in Biomedical Science and the 2015 Burroughs Wellcome Infectious Disease Investigator Award. Her main research focus is on structural and biochemical mechanism of the immune system. Abstract: Efficient host defense against viral infection depends on proper functions of pattern recognition receptors. One such family of receptors consists of RIG-I and MDA5, well-conserved cytoplasmic helicases that detect viral RNAs during infection and activate the type I interferon (IFN) signaling pathway. Dr. Hur's laboratory has investigated the molecular mechanisms by which these receptors recognize viral dsRNAs and elicit the IFN response against a broad range of viruses. In particular, they have uncovered the filamentous assembly...
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