Ptp1b deletion in pro-opiomelanocortin neurons increases energy expenditure and impairs endothelial function via TNF-{alpha} dependent mechanisms

Conclusion: POMC-Ptp1b deletion increases plasma TNF-α levels, which contribute to body weight regulation via increased energy expenditure and impair endothelial function via COX-2 and ROS-dependent mechanisms.

Source: Clinical Science - March 2, 2016 Category: Biomedical Science Authors: Bruder-Nascimento, T., Kennard, S., Antonova, G., Mintz, J. D., Bence, K. K., Belin de Chantemele, E. J. Tags: PublishAheadOfPrint Source Type: research