Protein Phosphorylation and Cell Signaling in Cancer

NCI Center for Cancer Research Eminent Lecture Tony Hunter is the Renato Dulbecco Chair in Cancer Research, Director of the Salk Institute Cancer Center and an American Cancer Society Professor in the Molecular and Cell Biology Laboratory at the Salk Institute for Biological Studies in La Jolla. In 1979, through his work on tumor viruses, he discovered a new class of protein kinase that phosphorylates tyrosine. He has spent most of the last 35 years studying protein kinases and phosphatase, and the role of protein phosphorylation in cell proliferation and the cell cycle, and how aberrant protein phosphorylation can cause cancer. His group also works on other types of posttranslational modifications (PTMs), including ubiquitylation and sumoylation, and crosstalk between PTMs. He has received many awards for his work on tyrosine phosphorylation, and is a member of several academic societies including the US National Academy of Sciences and the Royal Society of London. Post-translational modification (PTM) is a means of increasing the complexity of the proteome, and reversible PTMs are commonly used in the transmission of signals within cells in response to external stimuli. Protein phosphorylation is involved in the majority of cellular processes and thousands of distinct phosphorylation events can be detected in a single cell type. The human kinome comprises >530 protein kinases of which 480 are typical eukaryotic protein kinases (ePKs), and the remainder are atypical prote...
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