Effects of Oral Anticoagulant Therapy in Medical Inpatients ≥65 Years With Atrial Fibrillation

In this retrospective cohort observational study, we investigated mortality, ischemic, and hemorrhagic events in patients ≥65 years with atrial fibrillation consecutively discharged from an Acute Geriatric Ward in the period 2010 to 2013. Stroke and bleeding risk were evaluated using CHA2DS2-VASC (congestive heart failure/left ventricular dysfunction, hypertension, aged ≥75 years, diabetes mellitus, stroke/transient ischemic attack/systemic embolism, vascular disease, aged 65 to 74 years, gender category) and HAS-BLED (hypertension, abnormal renal/liver function, stroke, bleeding history or predisposition, labile international normalized ratio, elderly, drugs/alcohol concomitantly) scores.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Tags: Arrhythmias and Conduction Disturbances Source Type: research

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Authors: Li W, Zhou Y, Shang C, Sang H, Zhu H Abstract Background: Proton pump inhibitor (PPI) and other acid-suppressing drugs are widely used in the treatment of gastrointestinal ulcer, upper gastrointestinal bleeding, gastritis, and gastric cancer (GC). About 80% of GC patients receive acid suppression treatment. PPI suppresses the production of gastric acid by inhibiting the function of H+/K+-ATPase in gastric parietal cells and raises the pH value to achieve therapeutic purposes. Some studies have found that PPI had a certain antitumor effect in the proliferation and apoptosis of tumor cells. But the effects o...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
We present an up-to-date systematic review of the current literature regarding the safety in artificial and natural sweeteners use as a means of weight loss or diabetes control.Expert opinion: Natural sweeteners have not been associated directly with NAFLD, and on the contrary, some, such as stevia, and trehalose, may have a protective effect. Rare sugars and polyols can be used safely and have significant benefits that include anti-oxidant effect and optimal glycemic control. Artificial sweeteners, due to their effect on NAFLD development and insulin resistance, are not indicated in patients with obesity or diabetes. Furt...
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
Conclusion: Serum GGT level was a significant predictor of subsequent risk of diabetes mellitus, which increased by 4% for every 1 IU/L increase in GGT when GGT was less than 24 IU/L. PMID: 32215009 [PubMed]
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
In this study, we aimed to evaluate the influence of insulin production on immune system after the onset of diabetes, and we showed that the duration of honeymoon period could be related to the onset of other autoimmune conditions. For this retrospective study, 159 children aged between 11 and 18 years with type 1 DM were eligible. They have been diagnosed diabetes at least 10 years ago and use exogenous insulin. Our results showed that younger age at the onset of Type 1 DM in children, predicts Celiac Disease. Female sex and low HCO3 levels at the onset of DM had a high predictive value on patients who did not experience ...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Publication date: Available online 27 March 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Feiyan Liu, Yu Liu, Xizhuo Sun, Zhaoxia Yin, Honghui Li, Kunpeng Deng, Yang Zhao, Bingyuan Wang, Yongcheng Ren, Xuejiao Liu, Dongdong Zhang, Xu Chen, Cheng Cheng, Leilei Liu, Dechen Liu, Guozhen Chen, Shihao Hong, Chongjian Wang, Ming Zhang, Dongsheng Hu
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Publication date: Available online 27 March 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Alvaro Alonso, Mary R. Rooney, Lin Yee Chen, Faye L. Norby, Amy K. Saenger, Elsayed Z. Soliman, Wesley T. O’Neal, Katie C. Hootman, Elizabeth Selvin, Pamela L. Lutsey
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Serious Complication of Anticoagulation in Vessel Thrombosis-associated Behçet Disease. Intern Med. 2020 Mar 26;: Authors: Ouchi K, Narui R, Sakuma T, Ojiri H Abstract Anticoagulation in venous thrombosis associated with Behçet disease (BD) is controversial. We herein report a 47-year-old woman with vessel thrombosis and pulmonary artery aneurysm (PAA) associated with BD who died of massive hemoptysis under oral anticoagulant. Although she was initially diagnosed with oral contraceptive-induced venous thromboembolism, a subsequent investigation led to a diagnosis of BD. Follow-up computed...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Publication date: Available online 27 March 2020Source: Journal of Hospital InfectionAuthor(s): H.J. Breidablik, D.E. Lysebo, L. Johannesse, Å. Skare, O. Kleiven, J.R. Andersen
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
The objective was to investigate sleep disorders and associated sociodemographic and behavioral factors. A census of university students was carried out. Questions extracted from the Munich Chronotype Questionnaire investigated: insufficient sleep duration (
Source: Cadernos de Saude Publica - Category: International Medicine & Public Health Authors: Tags: Cad Saude Publica Source Type: research
Publication date: Available online 27 March 2020Source: Molecular MetabolismAuthor(s): Lucia Russo, Lindsey Muir, Lynn Geletka, Jennifer Delproposto, Nicki Baker, Carmen Flesher, Robert O’Rourke, Carey N. Lumeng
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
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