Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes
Conclusion: Computational modeling of available in vivo and in vitro data for chemicals that produce adverse effects on male reproductive endpoints revealed a phenotypic hierarchy across animal studies consistent with the human TDS hypothesis. We confirmed the known role of estrogen and androgen signaling pathways in rodent TDS, and importantly, broadened the list of molecular targets to include retinoic acid signaling, vascular remodeling proteins, G-protein coupled receptors (GPCRs), and cytochrome-P450s.
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Citation: Leung MC, Phuong J, Baker NC, Sipes NS, Klinefelter GR, Martin MT, McLaurin KW, Setzer RW, Darney SP, Judson RS, Knudsen TB. Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1510385
Received: 24 June 2015
Accepted: 24 November 2015
Advance Publication: 11 December 2015
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Source: EHP Research - Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research
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