6 Things To Know About Uterus Transplants In The U.S.

Ten women in the United States will soon be chosen to undergo the nation's first uterus transplants, as part of a study at the Cleveland Clinic. Doctors at the hospital hope to perform the first uterus transplant in the next few months, according to the New York Times. The procedure is still highly experimental, and not all of the risks are known. Here's what you need to know about uterus transplants: Who needs a uterus transplant? The new study will involve women with a condition called uterine factor infertility, which means they cannot become pregnant either because they were born without a uterus, or their uterus was removed by hysterectomy, or it was damaged by an injury or infection so that it no longer functions, according to the Cleveland Clinic. Women ages 21 to 45 are eligible for the study, but those 40 and older must have undergone fertility treatments to create and freeze embryos before they were 39, the Clinic says. About 1 in 4,500 women in the United States is born without a uterus - a condition known as Mayer-Rokitansky-Küster-Hauser syndrome, according to the NIH. Has this been done before? Uterus transplants have been completed successful before, in Sweden. In a study done there, nine women received uterus transplants, five became pregnant, and four have given birth so far. However, unlike the study in Sweden, in which patients received uteruses that were donated by living relatives, the study at the Cleveland Clinic will use deceased donors....
Source: Science - The Huffington Post - Category: Science Source Type: news

Related Links:

Authors: Honrubia-Gómez P, López-Garrido MP, Gil-Gas C, Sánchez-Sánchez J, Alvarez-Simon C, Cuenca-Escalona J, Perez AF, Arias E, Moreno R, Sánchez-Sánchez F, Ramirez-Castillejo C Abstract Relapse after chemotherapy treatment depends on the cancer initiating cells (CICs). PEDF (Pigmented Epithelium Derived Factor) is an anti-angiogenic, neurotrophic and self-renewal regulator molecule, also involved in CICs biology. Acute and chronic exposition of colon cancer cell lines to CT/CTE PEDF-derived peptides decreased drug-resistance to conventional colorectal cancer treatments, ...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: PMID: 31104530 [PubMed - as supplied by publisher]
Source: Hypertension in Pregnancy - Category: OBGYN Tags: Hypertens Pregnancy Source Type: research
Publication date: Available online 21 May 2019Source: American Journal of Kidney DiseasesAuthor(s): Meera Nair Harhay, Karthik Ranganna, Suzanne M. Boyle, Antonia M. Brown, Thalia Bajakian, Lissa B. Levin Mizrahi, Gary Xiao, Stephen Guy, Gregory Malat, Dorry L. Segev, David Reich, Mara McAdams-DeMarcoRationale &ObjectiveThere is debate on whether weight loss, a hallmark of frailty, signals higher risk for adverse outcomes among recipients of deceased donor kidney transplantation (DDKT).Study DesignRetrospective cohort study.Setting &ParticipantsUsing national Organ Procurement and Transplantation Network data, we i...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
In this study, the experimental autoimmune encephalomyelitis (EAE) model, which is the most commonly model to mimic MS, was successfully established in cynomolgus monkeys. To evaluate the therapeutic effect of human umbilical cord mesenchymal stem cells (UCMSCs) on MS, we intravenously transplanted UCMSCs into cynomolgus monkeys with EAE. Our results showed that UCMSC transplantation significantly ameliorated the clinical symptoms of MS. Magnetic resonance imaging and clinical signs indicated that demyelination was obviously decreased after UCMSCs therapy. Moreover, the present study showed that the mechanisms, involved in...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
This study assessed the antifibrotic effects of hHSPCs in mice with fibrosis induced by carbon tetrachloride (CCl4) and examined the actions of hHSPCs on the fibrogenic activity of human hepatic stellate cells (HSCs) in a coculture system. Isolated hHSPCs expressed stem/progenitor cell phenotypic markers. Mice were given CCl4 (twice weekly for 7 weeks) and hHSPC transplantation weekly. CCl4 induced advanced fibrosis (bridging fibrosis and cirrhosis) in mice, which was prevented by hHSPC transplantation. The liver of hHSPC-transplanted mice showed only occasional short septa and focal parenchymal fibrosis, and a 50% reducti...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
The objective of the present study was to explore whether AT1-AA induced cardiomyocyte apoptosis was related to its inhibitory of miR-21 expression. In vivo studies, the pregnant rats were divided into two groups: Sham group, Model group. The pathology, cell apoptosis, and relative protein expressions were evaluated by hematoxylin and eosin staining, and Western blot assay. The expression of microRNA was detected by gene microarray. In the cell experiment, the neonatal rat cardiomyocytes were divided into four groups: NC group, AT1-AA group, and miR-21 group and AT1-AA+miR-21 group. The cell apoptosis and relative proteins...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
This study demonstrated that TGF-β3 and KGN exhibit synergistic effects for the promotion of the chondrogenesis of rabbit SF-MSCs and can effectively repair cartilage defects through the regeneration of hyaline cartilage. PMID: 31105817 [PubMed]
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
This report describes the unusual complication of a tilted, penetrating, and fractured Cook Celect (Bloomington, IN) inferior vena cava (IVC) filter in a young patient that resulted in appendicitis and was exempt from institutional review board approval at the originating institution.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Letter to the Editor Source Type: research
On an afternoon in November, a couple hosted a birthday party for their 1-year-old son. As family and friends gathered around the child to sing “Happy Birthday,” his parents addressed a milestone that reached well beyond the room. “It was emotional,” recalls the mother. “It took a lot more than a nine-month pregnancy to get him, and we wouldn’t be where we are without everyone’s support.” Many parents will tell you their child is miraculous. But the mere existence of this particular boy, who just a month earlier had taken his first steps, brings the miracle somehow closer to ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized fertility Research Source Type: news
The world’s first baby born by a uterus transplant from a deceased donor is healthy and nearing her first birthday, according to a new case study published Tuesday in the Lancet. Uterus transplants have become more common in recent years, resulting in 11 live births around the world. But all of the other successful deliveries so far have been made possible by living donors — often women who opt to donate their uterus to a close friend or family member without one. The birth resulting from the case detailed in the Lancet, which took place at Brazil’s Hospital das Cli╠ünicas last December, is both the first...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized fertility healthytime Source Type: news
More News: Babies | Cesarean Section | Children | Education | Health | Hospitals | Hysterectomy | Infertility | Kidney Transplant | Kidney Transplantation | Medical Ethics | MRKH Syndrome | New York University | Ovaries | Pregnancy | Reproduction Medicine | Science | Study | Transplant Surgery | Transplants | Universities & Medical Training | Urology & Nephrology | Websites | Women