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6 Things To Know About Uterus Transplants In The U.S.

Ten women in the United States will soon be chosen to undergo the nation's first uterus transplants, as part of a study at the Cleveland Clinic. Doctors at the hospital hope to perform the first uterus transplant in the next few months, according to the New York Times. The procedure is still highly experimental, and not all of the risks are known. Here's what you need to know about uterus transplants: Who needs a uterus transplant? The new study will involve women with a condition called uterine factor infertility, which means they cannot become pregnant either because they were born without a uterus, or their uterus was removed by hysterectomy, or it was damaged by an injury or infection so that it no longer functions, according to the Cleveland Clinic. Women ages 21 to 45 are eligible for the study, but those 40 and older must have undergone fertility treatments to create and freeze embryos before they were 39, the Clinic says. About 1 in 4,500 women in the United States is born without a uterus - a condition known as Mayer-Rokitansky-Küster-Hauser syndrome, according to the NIH. Has this been done before? Uterus transplants have been completed successful before, in Sweden. In a study done there, nine women received uterus transplants, five became pregnant, and four have given birth so far. However, unlike the study in Sweden, in which patients received uteruses that were donated by living relatives, the study at the Cleveland Clinic will use deceased donors....
Source: Science - The Huffington Post - Category: Science Source Type: news

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Authors: Klein S, Aung T, Haas RM, Medved F, Schiller SM, Felthaus O, Dolderer JH Abstract Soft tissue defects resulting from injuries, tumor resection, congenital anomalies or chronic wounds pose a great challenge to reconstructive surgery. The current gold standard in therapy of such defects is the tissue transplantation in terms of free or local flaps. Unfortunately, donor site morbidity remains a considerable risk of flap surgery. Therefore, tissue engineering of autologous vascularized long term stable adipose tissue constructs could enrich the therapeutic possibilities of soft tissue defects. De novo adipose ...
Source: Handchirurgie Mikrochirurgie Plastische Chirurgie - Category: Cosmetic Surgery Tags: Handchir Mikrochir Plast Chir Source Type: research
Authors: Fung C, Dinh P, Ardeshir-Rouhani-Fard S, Schaffer K, Fossa SD, Travis LB Abstract Testicular cancer has become the paradigm of adult-onset cancer survivorship, due to the young age at diagnosis and 10-year relative survival of 95%. This clinical review presents the current status of various treatment-related complications experienced by long-term testicular cancer survivors (TCS) free of disease for 5 or more years after primary treatment. Cardiovascular disease and second malignant neoplasms represent the most common potentially life-threatening late effects. Other long-term adverse outcomes include neuro...
Source: Advances in Urology - Category: Urology & Nephrology Tags: Adv Urol Source Type: research
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Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
In this study, we establish the procedure for preparing skin fibroblast clones whose genes were edited by the CRISPR/Cas9 technique. After isolating fibroblasts from earlobes of Japanese Black cattle, subsequent collagenase-digestion and extensive wash procedures enabled us to avoid contamination of fungi. Electroporation using NEPA21, rather than lipofection using commercially available liposome reagents, allowed us to perform more efficient transfection of plasmid constructs. Although bovine ear-derived fibroblasts were not able to proliferate in single cell cultures in Dulbecco's modified Eagle medium containing 10% fet...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Source Type: research
This study aimed to evaluate the impact of donor HTN on patient survival of SLKT recipients and to identify independent risk factors. MATERIAL AND METHODS Data from 3844 adult SLKT recipients receiving deceased donor grafts from March 2002 to December 2014 in the Scientific Registry of Transplant Recipients (SRTR) database were retrospectively analyzed. Kaplan-Meier analysis was used to compare patient and graft survival. Multivariate Cox proportional hazard models were built to identify independent risk factors associated with patient and graft survival. RESULTS SLKT patients receiving HTN donor grafts had significantly s...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSION: Our observations highlight the difficulty to diagnose this complication with often non-specific clinical presentation and possible delayed occurrence after to transplantation, but also the therapeutic challenges, defibrotide being the only agent currently efficient. Physiopathology and potential responsibility of bendamustine in the sinusoidal obstruction syndrome occurrence will be discussed. PMID: 29673920 [PubMed - as supplied by publisher]
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CONCLUSIONS: Accidental rectus muscle disinsertion after pterygium excision surgery is a serious but rare postoperative complication of pterygium surgery. Great care should be taken intraoperatively to avoid this complication. Reattachment of the disinserted medial rectus will produce a satisfactory resolution of the problem. PMID: 29672190 [PubMed - as supplied by publisher]
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Authors: Kwak KA, Cho HJ, Yang JY, Park YS Abstract Liver cirrhosis is a major cause of mortality and a common end of various progressive liver diseases. Since the effective treatment is currently limited to liver transplantation, stem cell-based therapy as an alternative has attracted interest due to promising results from preclinical and clinical studies. However, there is still much to be understood regarding the precise mechanisms of action. A number of stem cells from different origins have been employed for hepatic regeneration with different degrees of success. The present review presents a synopsis of stem ...
Source: Canadian Journal of Gastroenterology - Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research
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Source: Journal of Psychosomatic Obstetrics and Gynaecology - Category: OBGYN Tags: J Psychosom Obstet Gynaecol Source Type: research
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Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research
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