Genetic stability of live attenuated vaccines against potentially pandemic influenza viruses.

CONCLUSIONS: Our clinical trials revealed phenotypic and genetic stability of the LAIV viruses recovered from the immunized volunteers. In addition, no vaccine virus was detected in the placebo groups indicating the lack of person-to-person transmission. LAIV TRIAL REGISTRATION at ClinicalTrials.gov: H7N3-NCT01511419; H5N2-NCT01719783; H2N2-NCT01982331.
PMID: 26432909 [PubMed - as supplied by publisher]

Source: Vaccine - September 30, 2015 Category: Allergy & Immunology Authors: Kiseleva I, Dubrovina I, Fedorova E, Larionova N, Isakova-Sivak I, Bazhenova E, Pisareva M, Kuznetsova V, Flores J, Rudenko L Tags: Vaccine Source Type: research