Does Fertility Treatment Increase the Risk of Uterine Cancer? A Meta-Analysis

Publication date: Available online 3 October 2015 Source:European Journal of Obstetrics & Gynecology and Reproductive Biology Author(s): Srdjan Saso, Louay S. Louis, Farah Doctor, Ali Hassan Hamed, Jayanta Chatterjee, Joseph Yazbek, Shabana Bora, Hossam Abdalla, Sadaf Ghaem-Maghami, Meen-Yau Thum An ongoing debate over the last two decades has focused on whether fertility treatment in women may lead to an increased risk of developing uterine cancer over a period of time. Uterine cancer (including mainly endometrial carcinoma and the less common uterine sarcoma) is the commonest reproductive tract cancer and the fourth commonest cancer in women in the UK. Our objective was to assess the association between fertility drugs used in the treatment of female infertility (both as an independent therapy and during in vitro fertilization cycles) and the development of uterine cancer. A literature search was performed using Medline, Embase, Cochrane Library and Google Scholar databases for comparative studies until December 2014 to investigate a clinical significance of fertility treatment on the incidence of developing uterine cancer. General and MESH search headings, as well as the ‘related articles’ function were applied. All comparative studies of ‘fertility treatment’ versus ‘non-fertility treatment’ reporting the incidence of uterine cancer as an outcome were included. Uterine cancer incorporated the following terms: uterine can...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research

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Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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