Cardiopulmonary transplantation

Publication date: Available online 8 September 2015 Source:Anaesthesia & Intensive Care Medicine Author(s): Barbora Parizkova, I Gavin Wright More than 7000 cardiopulmonary transplants were carried out worldwide in 2012 across the 388 centres reporting to the International Registry. The Registry of the International Society for Heart and Lung Transplantation reported 4196 heart transplants and 3812 lung transplants worldwide in 2012. The 100,000th heart transplant mark has been passed. Heart transplantation is a proven surgical option for selected patients who have advanced heart failure refractory to surgical or medical management. Lung transplantation is the definitive treatment for end-stage lung disease for patients who have failed medical therapy. More than 90% of adult patients presenting for heart transplantation have dilated cardiomyopathy or ischaemic cardiomyopathy. Anaesthetic principles for heart transplantation include full monitoring including transoesophageal echocardiography, cardiostable anaesthesia and cardiac support, and assessment and treatment of pulmonary vascular hypertension. Median survival after cardiac transplantation is 11 years. Lung transplantation includes single-lung, double-lung, bilateral sequential single-lung, heart-lung and lobar transplantation. The most common indication is chronic obstructive pulmonary disease, which represents more than one-third of all transplant recipients. Donor criteria are becoming more liberal. Most lung...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research

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DiscussionMCI prevalence varied among Hispanic/Latino backgrounds, but not as widely as reported in the previous studies. CVD risk and depressive symptoms were associated with increased MCI, whereas APOE4 was not, suggesting alternative etiologies for MCI among diverse Hispanics/Latinos. Our findings suggest that mitigating CVD risk factors may offer important pathways to understanding and reducing MCI and possibly dementia among diverse Hispanics/Latinos.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Publication date: Available online 17 November 2019Source: Pharmacological ResearchAuthor(s): Qiujin Jia, Lirong Wang, Xiaonan Zhang, Yuejia Ding, Hao Li, Yingxi Yang, Ao Zhang, Yanyang Li, Shichao Lv, Junping ZhangAbstractIn recent years, although the concept and means of modern treatment of chronic heart failure(CHF) are continually improving, the readmission rate and mortality rate are still high. At present, there is evidence that there is a link between gut microbiota and heart failure, so the intervention of gut microbiota and its metabolites is expected to become a potential new therapeutic target in heart failure. ...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
ConclusionsAn improvement in efficacy could not be observed after modified DHAP regimen; however, manageable toxicity and reduced renal complications suggest further investigation. The study, however, also underlines the need for new concepts in the management of advanced and high-risk lymphomas.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Use this guide to help you talk to your healthcare provider about medicines called antidepressants that can help treat depression. Ask your healthcare provider to tell you about the risks of taking this type of medicine. This guide only covers some of the risks.
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news
ConclusionsCSU has strong negative effects on female sexual function, especially in patients with angioedema. Additional studies on sexual health in patients with CSU are needed and should focus on the impact of effective treatment on sexual functioning.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 18 November 2019Source: Journal of Psychiatric ResearchAuthor(s): Sophia C. Gaynor, Eric T. Monson, Marie E. Gaine, Michael S. Chimenti, Rachel D. Reichman, Meredith Parsons, Lalita Oonthonpan, Peter P. Zandi, James B. Potash, Virginia L. WillourAbstractWe previously conducted a genome-wide association study (GWAS) of attempted suicide within bipolar disorder, which implicated common variation in the 2p25 region primarily in males. The top association signal from our GWAS occurred in an intergenic region of 2p25 (p = 5.07 × 10−8) and was supported by two independent st...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
ConclusionsCurrent evidence supports a significant association between history of PMS and development of PPD. Well-designed prospective studies are needed to further investigate this relationship.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
A single, low-dose ketamine infusion was relatively free of side effects for patients with treatment-resistant depression.
Source: National Institute of Mental Health - Category: Psychiatry Authors: Source Type: news
The basic science underlying biological psychiatry came first from animal models. For example, rodent studies established the pathways through which early-life experience and stress impact brain systems involved in anxiety and depression (1). With the advent of modern neuroimaging it became possible to study these systems as they function in healthy humans and in those with psychiatric disorders (2).
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
Publication date: June 2018Source: Anaesthesia &Intensive Care Medicine, Volume 19, Issue 6Author(s): Barbora Parizkova, Gavin WrightAbstractThe Registry of the International Society for Heart and Lung Transplantation reported 4196 heart transplants and 3812 lung transplants worldwide in 2015. The 100,000th heart transplant mark has been passed. Heart transplantation is a proven surgical option for selected patients who have advanced heart failure refractory to surgical or medical management. Lung transplantation is the definitive treatment for end-stage lung disease for patients who have failed medical therapy. More t...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
More News: Anesthesia | Anesthesiology | Cardiology | Cardiomyopathy | Chronic Obstructive Pulmonary | Depression | Dilated Cardiomyopathy | Heart | Heart Failure | Heart Transplant | Hypertension | Intensive Care | Lung Transplant | Respiratory Medicine | Transplant Surgery | Transplants