GPR30 selective agonist G-1 induced insulin resistance in ovariectomized mice on high fat diet and its mechanism

CONCLUSION: Despite G-1's the potential efficacy in weight reduction, the concomitant induction of insulin resistance and cardiac impairment in conjunction with an HFD raises significant concerns. Therefore, comprehensive studies of its safety profile and effects under specific conditions are essential prior to clinical use.PMID:38701557 | DOI:10.1016/j.bbrc.2024.150026

Source: Biochemical and Biophysical Research communications - May 3, 2024 Category: Biochemistry Authors: Congcong Lu Da Liu Min Li Xiaocui Shi Jingyue Guan Guoyuan Song Yajuan Yin Mingqi Zheng Fangfang Ma Gang Liu Source Type: research