Immunologic Synapse Formation Between Mouse Dorsal Root Ganglion Neurons and CD4+ T Cells Induces CD4+ T Cell Cytokine Production

Chemotherapy can be a life-saving treatment, but development of chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting toxicity. Recent studies demonstrate that paclitaxel (PTX) increases anti-inflammatory CD4+ T cells in the dorsal root ganglia (DRG), and that T cells and anti-inflammatory cytokines are protective against CIPN. We found that DRG neurons express major histocompatibility II (MHCII) protein, and that reducing neuronal MHCII exacerbates PTX-induced cold hypersensitivity in male and female mice.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research