Impact of Resiniferatoxin on Oral Squamous Cell Carcinoma Pain and Tumor-Associated Immune Response

Oral squamous cell carcinoma (oSCC) is one of the most painful cancers. TRPV1+ nociceptive afferents have been implicated in cancer pain and immunosuppression. We hypothesize that prophylactic denervation of peptidergic sensory neurons using resiniferatoxin (RTX) will reduce cancer pain and improve anti-tumor immunity. To test this hypothesis, we used syngeneic orthotopic transplant mouse models. Nociceptive behavior and nerve injury were assessed using the dolognawmeter and immunohistochemistry, respectively.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research