Heparanase promotes the onset and progression of atherosclerosis in apolipoprotein E gene knockout mice

CONCLUSIONS: This study identifies Hpse as a key pro-inflammatory enzyme driving the initiation and progression of atherosclerosis and highlighting the potential of Hpse inhibitors as novel anti-inflammatory treatments for cardiovascular disease.PMID:38581737 | DOI:10.1016/j.atherosclerosis.2024.117519

Source: Atherosclerosis - April 6, 2024 Category: Cardiology Authors: Tien K Nguyen Stephanie Paone Amy A Baxter Alyce J Mayfosh Thanh Kha Phan Enoch Chan Karlheinz Peter Ivan K H Poon Shane R Thomas Mark D Hulett Source Type: research