SIRT3 alleviates painful diabetic neuropathy by mediating the FoxO3a-PINK1-Parkin signaling pathway to activate mitophagy

CONCLUSION: These results showed that SIRT3 overexpression ameliorates PDN via activation of FoxO3a-PINK1-Parkin-mediated mitophagy, suggesting that SIRT3 may become an encouraging therapeutic strategy for PDN.PMID:38572816 | DOI:10.1111/cns.14703

Source: CNS Neuroscience and Therapeutics - April 4, 2024 Category: Neuroscience Authors: Jing Yang Zhuoying Yu Ye Jiang Zixian Zhang Yue Tian Jie Cai Min Wei Yanhan Lyu Dongsheng Yang Shixiong Shen Guo-Gang Xing Min Li Source Type: research