Family History of Treatment-Resistant Depression May Be Risk Factor for Antidepressant Resistance

Individuals with a family history of treatment-resistant depression (TRD) have an increased risk of experiencing antidepressant resistance themselves, astudy published yesterday inJAMA Psychiatry found. Further, individuals with a family history of TRD have a greater risk of other psychiatric illnesses and dying by suicide.“In recent years, an increasing number of genetic studies have attempted to understand the genetic architecture of antidepressant response or TRD phenotype,” wrote Chih-Ming Cheng, M.D., of the Taipei Veterans General Hospital in Taiwan and colleagues. “Although the efforts to understand the g enetic mechanism behind antidepressant response are promising, these positive results require more replication and must overcome methodological concerns, such as relatively small sample size and diverse definitions of TRD.”Cheng and colleagues used data from the Taiwan National Health Insurance program, which covers nearly the entire population of Taiwan and includes diagnoses of psychiatric disorders. The authors used all medical records from 2003 to 2017, which were linked to records from the Database of National Mortality Registry to determine date and cause of death. Patients who were diagnosed with major depressive disorder and received at least three adequate antidepressant trials (exceeding 56 daily doses in an eight-week period) within two years were defined as having TRD. In total, 21,046 individuals met these criteria. The authors then identified 34,...
Source: Psychiatr News - Category: Psychiatry Tags: ADHD antidepressant resistance anxiety bipolar disorder Chih-Ming Cheng family risk factors genetics OCD schizophrenia suicide Taiwan National Health Insurance Program treatment-resistant depression Source Type: research