The SWI/SNF subunit ARID1A mediates neutrophil associated skin inflammatory responses

AT-rich interaction domain 1A (ARID1A) is part of the Switch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex that plays important roles in development and disease by altering chromatin structure through ATP hydrolysis (Pulice and Kadoch, 2016). ARID1A binds to AT-rich DNA sequences through its ARID domain and is expressed in most cell types. ARID1A is one of the most heavily mutated SWI/SNF complex member and loss of function mutations has been linked to various cancers including endometrial, bladder, gastric, hepatocellular carcinoma, cholangiocarcinoma, melanoma, colorectal, lung, pancreatic, and breast cancer (Helming et al., 2014).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research