The effects of replacing ghee with rapeseed oil on liver steatosis and enzymes, lipid profile, insulin resistance, and anthropometric measurements in patients with non-alcoholic fatty liver disease: A randomized controlled clinical trial

Br J Nutr. 2024 Mar 19:1-30. doi: 10.1017/S0007114524000564. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease, which is a prevalent hepatic condition worldwide, is expected to develop into the leading reason for end-stage fatty liver in the forthcoming decades. Incorporating Rapeseed oil into a balanced diet may be beneficial in improving NAFLD. The goal of this trial was to evaluate the impact of substituting ghee with rapeseed oil on primary outcomes such as fatty liver and liver enzymes, as well as on secondary outcomes including glycemic variables, lipid profile, and anthropometric measurements in individuals with NAFLD. Over 12 weeks, 110 patients [70 men and 40 women; BMI (mean ± SD): 28.2 ± 1.6 kg/m2; mean age: 42 ± 9.6 y], who daily consumed ghee, were assigned to the intervention or control group through random allocation. The intervention group, was advised to substitute ghee with rapeseed oil in the same amount. The control group continued consumption of ghee and was instructed to adhere a healthy diet. Results showed a significant reduction in the steatosis in the intervention group in comparison to the control group (P<0.001). However, a significant change in the levels of ALT (-14.4 IU/l), GGT (-1.8 IU/l), TG (-39.7 mg/dl), TC (-17.2 mg/dl), LDL (-7.5 mg/dl), FBS (-7.5 mg/dl), Insulin (-3.05 mU/l), HOMA-IR (-0.9), QUICKI (+0.01), weight (-4.3 kg), BMI (-0.04 kg/m2), waist (-5.6 cm) and waist to height ratio (-0.04) was seen in the interventi...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Source Type: research