Natural history of craniovertebral abnormalities in a single-center study in 54 patients with Hurler syndrome

CONCLUSIONS: Based on the data, the authors observed an increase in canal width and pB-C2, whereas the CXA and odontoid retroflexion angle became more acute as the patients aged after HCT. The longitudinal models derived from these data mirrored the development in children without MPS IH. Spinal measurements obtained on MR images alone are not sufficient in identifying patients who require surgical intervention. Symptom monitoring and clinical examination, as well as pathological spinal cord changes on MRI, are more crucial in assessing the need for surgery than is obtaining serial imaging.PMID:38489810 | DOI:10.3171/2024.1.PEDS23281

Source: Cancer Control - March 15, 2024 Category: Cancer & Oncology Authors: Shiwei Huang David R Nascene Ryan Shanley Isabela Pena-Pino Troy C Lund Ashish O Gupta Paul J Orchard Carolina Sandoval-Garcia Source Type: research