Nonclinical evaluation of chronic cardiac contractility modulation on 3D human engineered cardiac tissues

ConclusionThese data represent the first study of chronic CCM in a 3D ECT model, providing a nonclinical tool to assess the effects of cardiac electrophysiology medical device signals complementing in vivo animal studies. The methodology established a standardized 3D ECT-based in vitro testbed for chronic CCM, allowing evaluation of physiological and molecular effects on human cardiac tissues.

Source: Journal of Cardiovascular Electrophysiology - March 4, 2024 Category: Cardiology Authors: Tromondae K. Feaster, Jourdan K. Ewoldt, Anna Avila, Maura Casciola, Akshay Narkar, Christopher S. Chen, Ksenia Blinova Tags: ORIGINAL ARTICLE Source Type: research