Cellular iron depletion enhances behavioral rhythm by limiting brain Per1 expression in mice

CONCLUSION: These findings collectively suggest that altered iron levels influence the circadian rhythm by regulating PER1 expression and thereby modulating the molecular circadian clock. In conclusion, our study identifies the regulation of brain iron levels as a potential new target for treating age-related disruptions in the circadian rhythm.PMID:38385622 | PMC:PMC10883092 | DOI:10.1111/cns.14592

Source: CNS Neuroscience and Therapeutics - February 22, 2024 Category: Neuroscience Authors: Qiong Wu Qiuyang Ren Xin Wang Huiyuan Bai Dandan Tian Guofen Gao Fudi Wang Peng Yu Yan-Zhong Chang Source Type: research