Molecular prognostic of nine parthanatos death ‐related genes in glioma, particularly in COL8A1 identification

A total of 11 parthanatos genes from ParthanatosCluster database were used to obtain the 9 ParthanatosScore prognostic genes combination. ParthanatosScore was verified by 656 patients and 979 patients in TCGA and CGGA-LGG/GBM datasets. COL8A1 was screened from nine ParthanatosScore prognostic genes through the glioma cell lines and survival analysis. Silencing COL8A1 inhibited the malignant characterization. Temozolomide and AZD3759 inhibited COL8A1 expression and cell viability and promoted apoptosis and parthanatos gene expression, which is a target to improve glioma. CGGA, Chinese Glioma Genome Atlas; GBM, Glioblastoma; LGG, Low-Grade Glioma; TCGA, The Cancer Genome Atlas. AbstractPost-operative progression and chemotherapy resistance are the main causes of treatment failure in glioma patients. There is a lack of ideal prediction models for post-operative glioma patient progression and drug sensitivity. We aimed to develop a prognostic model of parthanatos mRNA biomarkers for glioma outcomes. A total of 11 parthanatos genes were obtained from ParthanatosCluster database. ConsensusClusterPlus and R “Limma” package were used to cluster The Cancer Genome Atlas (TCGA)-glioma cohort and analyze the differential mRNAs. Univariate Cox regression analysis, random survival forest model, and least absolute shrinkage and selection operator (LASSO) regression analysis were used to determine the nine ParthanatosScore prognostic genes combination. ParthanatosScore was verified by 65...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research