Cancers, Vol. 16, Pages 337: Hematological Neoplasms with Eosinophilia
Cancers, Vol. 16, Pages 337: Hematological Neoplasms with Eosinophilia
Cancers doi: 10.3390/cancers16020337
Authors:
Rosario M. Morales-Camacho
Teresa Caballero-Velázquez
Juan José Borrero
Ricardo Bernal
Concepción Prats-Martín
Eosinophils in peripheral blood account for 0.3–5% of leukocytes, which is equivalent to 0.05–0.5 × 109/L. A count above 0.5 × 109/L is considered to indicate eosinophilia, while a count equal to or above 1.5 × 109/L is defined as hypereosinophilia. In bone marrow aspirate, eosinophilia is considered when eosinophils make up more than 6% of the total nuclear cells. In daily clinical practice, the most common causes of reactive eosinophilia are non-hematologic, whether they are non-neoplastic (allergic diseases, drugs, infections, or immunological diseases) or neoplastic (solid tumors). Eosinophilia that is associated with a hematological malignancy may be reactive or secondary to the production of eosinophilopoietic cytokines, and this is mainly seen in lymphoid neoplasms (Hodgkin lymphoma, mature T-cell neoplasms, lymphocytic variant of hypereosinophilic syndrome, and B-acute lymphoblastic leukemia/lymphoma). Eosinophilia that is associated with a hematological malignancy may also be neoplastic or primary, derived from the malignant clone, usually in myeloid neoplasms or with its origin in stem cells (myeloid/lymphoid neoplasms with eosinophilia and tyrosine kina...
Source: Cancers - Category: Cancer & Oncology Authors: Rosario M. Morales-Camacho Teresa Caballero-Vel ázquez Juan Jos é Borrero Ricardo Bernal Concepci ón Prats-Martín Tags: Review Source Type: research