Aureusidin ameliorates 6-OHDA-induced neurotoxicity via activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway in SH-SY5Y cells and Caenorhabditis elegans

In conclusion, Aureusidin showed a neuroprotective effect in the 6-OHDA-induced PD model via activating Nrf2/HO-1 signaling pathway and prevented mitochondria-dependent apoptosis pathway, and these findings suggested that Aureusidin may be an effective drug for the treatment of PD.PMID:38056806 | DOI:10.1016/j.cbi.2023.110824

Source: Chemico-Biological Interactions - December 6, 2023 Category: Molecular Biology Authors: Kun Hu Susu Zhu Fanyu Wu Yongzhen Zhang Minyue Li Ling Yuan Wenjing Huang Yichi Zhang Jie Wang Jie Ren Hao Yang Source Type: research