Topical antimicrobial formulations using medicinal plant-derived essential oils targeting methicillin resistant < em > Staphylococcus aureus < /em >

Nat Prod Res. 2023 Dec 3:1-9. doi: 10.1080/14786419.2023.2287169. Online ahead of print.ABSTRACTMethicillin-resistant Staphylococcus aureus (MRSA) causes a variety of healthcare-associated and community-acquired infections. Due to limited availability of effective antimicrobials for treating MRSA infections, there is a growing need to explore alternative therapeutic approaches. Here, the antimicrobial activities of 19 oils, popularly used for their medicinal properties, were tested against MRSA USA300. Oils obtained from cinnamon, clove, tangerine, and coriander showed the most promising activities, demonstrating bactericidal, anti-adhesive and anti-biofilm activities, and synergistic properties with common antibiotics. Given that clove and cinnamon oils showed the best activities, they were incorporated into topical formulations. Not only did the formulations with oils maintain antimicrobial and anti-adhesive activities, but their anti-biofilm property was potentiated. Tests on Galleria mellonella larvae suggested that the formulation is non-toxic. The formulations proposed here are a great alternative for the decolonisation of surfaces containing MRSA and can help circumventing antimicrobial resistance, a growing threat in the hospital environment.PMID:38043125 | DOI:10.1080/14786419.2023.2287169
Source: Natural Product Research - Category: Biochemistry Authors: Source Type: research