Immunity impacts cognitive deficits across neurological disorders

Cognitive deficits are a common symptom of many neurodegenerative and neurological diseases such as multiple sclerosis, several dementias, mental health disorders, traumatic brain injury, and even normal aging. These disorders, despite their differences in etiology, feature prominent dysregulation of immune signaling molecules, including cytokines and chemokines. In this review, we highlight the association between several of these molecules with cognitive deficits observed in both patients and animal models, an understudied area of research. Understanding the immune dysregulation-associated commonalities between multiple pathological insults to the brain could uncover potential novel avenues of treatment for several neurological disorders that encompass cognitive decline. AbstractCognitive deficits are a common comorbidity with neurological disorders and normal aging. Inflammation is associated with multiple diseases including classical neurodegenerative dementias such as Alzheimer's disease (AD) and autoimmune disorders such as multiple sclerosis (MS), in which over half of all patients experience some form of cognitive deficits. Other degenerative diseases of the central nervous system (CNS) including frontotemporal lobe dementia (FTLD), and Parkinson's disease (PD) as well as traumatic brain injury (TBI) and psychological disorders like major depressive disorder (MDD), and even normal aging all have cytokine-associated reductions in cognitive function. Thus, there is like...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: REVIEW Source Type: research