A new, all-encompassing aetiology of type 1 diabetes
In conclusion, T1D is caused by a somatic mutation within the epitope-binding groove of an at-risk HLA gene that affects HLA-insulin-peptide-TCR complex binding affinity and initiates an autoimmune pathway. The nature of the peptide that binds to a mutated epitope-binding groove of an at-risk HLA gene determines the type of autoimmune disease that develops, that is, one at-risk HLA locus, multiple autoimmune diseases. Thus, T1D and AAIDs, and therefore common autoimmune diseases, share a similar somatic mutation-based aetiology.PMID:37772700 | DOI:10.1111/imm.13700
Source: Immunology - Category: Allergy & Immunology Authors: Piet C de Groen Source Type: research
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