An < em > in silico < /em > investigation: Can melatonin serve as an adjuvant in NR1D1-linked chronotherapy for amyotrophic lateral sclerosis?

This study provides preliminary data and lays the groundwork for future investigations involving in vitro (laboratory-based) and in vivo (animal or human-based) research on chronotherapy. In summary, this research highlights the potential of clock gene-related therapy utilizing melatonin in conjunction with FDA-approved drugs for amyotrophic lateral sclerosis treatment, offering insights into novel treatment strategies. The findings underscore the need for further studies to explore the effectiveness of this hypothetical approach in experimental and clinical settings.PMID:37781884 | DOI:10.1080/07420528.2023.2265476

Source: Chronobiology International - October 2, 2023 Category: Biology Authors: Emine Erdag Ismail Celil Haskologlu Merve Mercan Nurettin Abacioglu Ahmet Ozer Sehirli Source Type: research