Revising the roles of aldosterone in vascular physiology and pathophysiology: from electocortin to baxdrostat

Can J Cardiol. 2023 Sep 19:S0828-282X(23)01732-4. doi: 10.1016/j.cjca.2023.08.035. Online ahead of print.ABSTRACTAldosterone was initially identified as a hormone primarily related to regulation of fluid and electrolyte homeostasis. However, over the past twenty years there has been an increasing appreciation of its role in regulation of vascular function and pathophysiology in the setting of hypertension, atherosclerosis, and heart failure. The purpose of this review is to highlight recent advances in our understanding the biology of aldosterone as it relates to the pathophysiology and the management of vascular disease-especially related to hypertension. The review focuses on three key areas: 1) advances in our understanding of the cellular mechanisms by which aldosterone mediates its cellular effects, 2) identification of the hidden epidemic of aldosteronism as a mediator of hypertension and 3) appreciating new therapeutic advances in the clinical pharmacology of aldosterone inhibition in cardiovascular and renal disease.PMID:37734710 | DOI:10.1016/j.cjca.2023.08.035
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research