Prospective identification of variables as outcomes for treatment (PIVOT): study protocol for a randomised, placebo-controlled trial of hydroxyurea for Ghanaian children and adults with haemoglobin SC disease

DiscussionFor children and adults with HbSC disease, PIVOT will determine the safety of hydroxyurea and identify measurable changes in laboratory and clinical parameters, suitable for future prospective testing in a definitive multi-centre phase III clinical trial.Trial registrationPACTR, PACTR202108893981080. Registered 24 August 2021,https://pactr.samrc.ac.za
Source: Trials - Category: Research Source Type: clinical trials