Viruses, Vol. 15, Pages 1928: A Birth Cohort Follow-Up Study on Congenital Zika Virus Infection in Vietnam

Viruses, Vol. 15, Pages 1928: A Birth Cohort Follow-Up Study on Congenital Zika Virus Infection in Vietnam Viruses doi: 10.3390/v15091928 Authors: Michiko Toizumi Cuong Nguyen Vu Hai Thi Huynh Masafumi Uematsu Vy Thao Tran Hien Minh Vo Hien Anh Thi Nguyen Mya Myat Ngwe Tun Minh Xuan Bui Duc Anh Dang Hiroyuki Moriuchi Lay-Myint Yoshida We assessed the development, sensory status, and brain structure of children with congenital Zika virus (ZIKV) infection (CZI) at two years and preschool age. CZI was defined as either ZIKV RNA detection or positive ZIKV IgM and neutralization test in the cord or neonatal blood. Twelve children with CZI born in 2017–2018 in Vietnam, including one with Down syndrome, were assessed at 23–25.5 months of age, using Ages and Stages Questionnaire (ASQ-3), ASQ:Social-Emotional (ASQ:SE-2), Modified Checklist for Autism in Toddlers, automated auditory brainstem response (AABR), and Spot Vision Screener (SVS). They underwent brain CT and MRI. They had detailed ophthalmological examinations, ASQ-3, and ASQ:SE-2 at 51–62 months of age. None had birthweight or head circumference z-score < −3 except for the one with Down syndrome. All tests passed AABR (n = 10). No ophthalmological problems were detected by SVS (n = 10) and detailed examinations (n = 6), except for a girl’s astigmatism. Communication and problem-solving domains in a boy at 24 months,...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research