Adrenomedullin, transcriptionally regulated by vitamin D receptors, alleviates atherosclerosis in mice through suppressing AMPK-mediated endothelial ferroptosis

CONCLUSION: VDR inhibits ox-LDL-induced endothelial dysfunction and ferroptosis by regulating ADM transcription and acting on AMPK signaling pathway. Overexpression of VDR in Apoe-/- mice reduced lipid deposition and plaque area in the thoracic aorta of atherosclerotic mice.PMID:37688783 | DOI:10.1002/tox.23958

Source: Atherosclerosis - September 9, 2023 Category: Cardiology Authors: Yanchao Hu Xu Gu Yan Zhang Weidong Ma Lijun Sun Congxia Wang Bincheng Ren Source Type: research