Genes, Vol. 14, Pages 486: Impact of Advanced Paternal Age on Fertility and Risks of Genetic Disorders in Offspring

Genes, Vol. 14, Pages 486: Impact of Advanced Paternal Age on Fertility and Risks of Genetic Disorders in Offspring Genes doi: 10.3390/genes14020486 Authors: Kaltsas Moustakli Zikopoulos Georgiou Dimitriadis Symeonidis Markou Michaelidis Tien Giannakis Ioannidou Papatsoris Tsounapi Takenaka Sofikitis Zachariou The average age of fathers at first pregnancy has risen significantly over the last decade owing to various variables, including a longer life expectancy, more access to contraception, later marriage, and other factors. As has been proven in several studies, women over 35 years of age have an increased risk of infertility, pregnancy problems, spontaneous abortion, congenital malformations, and postnatal issues. There are varying opinions on whether a father’s age affects the quality of his sperm or his ability to father a child. First, there is no single accepted definition of old age in a father. Second, much research has reported contradictory findings in the literature, particularly concerning the most frequently examined criteria. Increasing evidence suggests that the father’s age contributes to his offspring’s higher vulnerability to inheritable diseases. Our comprehensive literature evaluation shows a direct correlation between paternal age and decreased sperm quality and testicular function. Genetic abnormalities, such as DNA mutations and chromosomal aneuploidies, and...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Review Source Type: research