Systematic review and meta-analysis of epidemiologic data on vaccine response in relation to exposure to five principal perfluoroalkyl substances

CONCLUSIONS: Epidemiologic data on immunosuppression and five principal PFAS suggest an association, with support across antibodies against multiple types of antigens. Data on Diphtheria, Rubella, and Tetanus were more supportive of an association than for other antibodies, and support was greater for associations with PFOA, PFOS, and PFHxS, than for PFNA or PFDA. The data on any specific antibody were scarce. Confounding factors that might account for the relation were not identified. Nearly all studies evaluated were judged to have a low or moderate risk of bias.PMID:36764183 | DOI:10.1016/j.envint.2023.107734

Source: Environment International - February 10, 2023 Category: Environmental Health Authors: Lori Crawford Scott A Halperin Michael W Dzierlenga Becky Skidmore Matthew W Linakis Shinichi Nakagawa Matthew P Longnecker Source Type: research