Abstract P1-08-02: Metformin blocks de novo synthesis of cholesterol in triple negative breast cancer cells

Conclusions: Metformin regulates cancer cells by multiple pathways including reduction in cell growth, increases in apoptosis and alterations in cellular metabolism. The effects on the cholesterol pathway are both extensive and affect multiple downstream pathways including EGFR, Akt, and MAPK. Partial funding was provided by the Susan G. Komen Foundation. Citation Format: Ann D Thor, Zeying Fan, Reema Wahdan-Alaswad, Steve M Anderson, Jennifer K Richer, Susan M Edgerton. Metformin blocks de novo synthesis of cholesterol in triple negative breast cancer cells [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P1-08-02.
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Session Abstracts Source Type: research