Laurie Letvak

Vice President and Head of Clinical Development Policy Dr. Laurie Letvak is Vice President and Head of Clinical Development Policy at Novartis, a position she has held since June 2014. Laurie has been with Novartis for 20 years in a variety of positions.  She played a key role in the development of Gleevec® since joining the International Project Team in 2001, responsible for Global Medical Affairs.   She led the development of the Medical Affairs program, which resulted in many key studies, some of which have provided the data for new indications for Gleevec ®, including Ph+ ALL and Adjuvant GIST.   From 2008-2012, she had been the Global Program Head for Glivec and Tasigna within Oncology Global Development at Novartis.  In this role was responsible for leading the global development efforts for both drugs, including registration programs for new indications.  Laurie assumed the position of Global Development Head for the  Critical Care Franchise  February, 2012.  In that role she was responsible for co-leading this worldwide franchise in partnership with the commercial head and in particular was responsible for the strategic development and execution of plans for development of the evolving portfolio, which focuses on specialty cardiovascular (with emphasis on heart failure) and metabolic products, particularly for lipids and atherosclerosis. Laurie  received her undergraduate and medical degrees from Cornell U...
Source: PHRMA - Category: Pharmaceuticals Authors: Source Type: news

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Abstract Takotsubo syndrome (TTS), also known as stress cardiomyopathy, is a type of acute heart failure syndrome triggered by intense psychological or physiological stress. TTS typically manifests as acute chest pain, dyspnea or syncope that mimics an acute myocardial infarction but does not involve coronary artery obstruction. The current understanding of the pathogenesis of TTS suggests that sympathetic nervous system (SNS) activation plays a central role. Specifically, stress can activate the SNS and lead to the over-release of catecholamine, which have toxic effects on myocardial tissue when present at excess...
Source: Cardiology Research and Practice - Category: Cardiology Authors: Tags: Cardiol Res Pract Source Type: research
AbstractAimsWe studied the association between android (A) to gynoid (G) fat ratio and functional capacity (peak VO2) in male patients with heart failure with reduced ejection fraction (HFrEF).Methods and resultsWe enrolled 118 male patients with HFrEF with left ventricular ejection fraction (LVEF) 25 kg/m2 with FNIH index 0.55 was detected in 60 patients. Relative peak VO2 was lower in patients with A/G ratio> 0.55 than in patients with A/G ratio
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
AbstractAimsThe PREPARE ‐MVR study (PRediction of Early PostoperAtive Right vEntricular failure in Mitral Valve repair (MVR) and to explore the associations between/Repair patients) sought to investigate the alterations of right ventricular (RV) contraction pattern in patients undergoing mitral valve replacement/repair ( MVR) and to explore the associations between pre‐operative RV mechanics and early post‐operative RV dysfunction (RVD).Methods and resultsWe prospectively enrolled 42 patients (63  ± 11 years, 69% men) undergoing open‐heart MVR. Transthoracic three‐dimensional (3D) echocardio...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
Authors: Choi Y, Yoo JH, Lee JH, Lee Y, Bae MK, Kim YD, Kim HJ Abstract Connective tissue growth factor (CTGF), an extracellular matrix protein with various biological functions, is known to be upregulated in multiple chronic diseases such as liver fibrosis and congestive heart failure, but the mechanism it undertakes to cause alveolar bone loss in periodontitis remains elusive. The present study therefore investigates the pathways involving CTGF in chronic periodontitis. RNA sequencing revealed a notable increase in the expression of CTGF in chronic periodontitis tissues. Also, TRAP staining, TRAP activity and bon...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Conditions:   Chronic Heart Failure;   Non-ischemic Cardiomyopathy;   Non-ischemic Dilated Cardiomyopathy Interventions:   Procedure: Cardiac catheterization;   Biological: Intracoronary administration of the umbilical cord-derived mesenchymal stromal cells Sponsors:   The Research-Clinical Center for Cardiac Surgery and Transplantology LLP;   State-Financed Health Facility " Samara Regional Medical Center Dinasty " Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 26 March 2020Source: Pharmacological ResearchAuthor(s): Gianfranco Sinagra, Ugo Corrà, Mauro Contini, Damiano Magrì, Stefania Paolillo, Pasquale Perrone Filardi, Susanna Sciomer, Roberto Badagliacca, Piergiuseppe Agostoni
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
The objectives of this review are, therefore: (i) to examine the sex‐speci fic dynamics of clinically relevant HF biomarkers in the general population, as well as in HF patients; (ii) to discuss the overlap between sex‐related and obesity‐related effects, and (iii) to identify knowledge gaps to stimulate research on sex‐related differences in HF.
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Review Source Type: research
(JAMA Network) A description of the presentation of acute myocardial inflammation in a patient with coronavirus disease 2019 (COVID-19) who recovered from influenzalike syndrome and developed fatigue and signs and symptoms of heart failure a week after upper respiratory tract symptoms.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 25 March 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Besmir Nreu, Ilaria Dicembrini, Federico Tinti, Giorgio Sesti, Edoardo Mannucci, Matteo Monami
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Ascites in heart failure – MCQ – Answer Ascites in heart failure is most likely to occur in – Correct answer: a) Constrictive pericarditis Though ascites can occur in any severe long standing heart failure, it is most likely to occur in constrictive pericarditis and severe tricuspid valve disease. The early occurrence of ascites in chronic constrictive pericarditis even before the appearance of generalised edema has been called ‘ascites precox’. Back to question
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Medicine MCQ - CVS Source Type: blogs
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