Prevalence of cardiovascular disease in alpha-1 antrypsin deficiency

We present prevalence of CVD from 1158 patients with AATD who are prospectively followed up as part of the Birmingham AATD registry in the UK. All diagnoses come from either central NHS records or patient reports.The prevalence of CVD was as follows: ischaemic heart disease, 5.2%; heart failure, 0.7%, myocardial infarction, 0.9%; stroke, 1.9%; atrial fibrillation 2.4%. Hypertension and hyperlipidaemia were present in 22% and 10.7% of patients respectively. Factors associated with a higher prevalence of CVD include being male (p <0.001), older age (p <0.001), lower KCO (p = 0.008) and presence of hyperlipidaemia or hypertension (p <0.001). There was no statistical difference in prevalence of CVD for FEV1, smoking history or severity of AAT phenotype.These results suggest that AATD alone may not associated with the prevalence of CVD. Further data from hospital episode statistics is being gathered to help track hospitalisations due to cardiovascular disease and the relationship between pulmonary exacerbations and prevalence of CVD to strengthen our conclusions.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 05.02 - Monitoring airway disease Source Type: research