Current German Guidelines on Diagnosis and Treatment of Secondary Hemochromatosis in Patients with Congenital Anemias
Klin Padiatr 2022; 234: 368-373 DOI: 10.1055/a-1925-7345Adequate diagnosis and treatment of secondary hemochromatosis in patients with
congenital anemias is important for reducing long-term mortality and morbidity
as for improving patients' quality of life. Due to the strong migration
movements during recent years, the number of patients in Germany suffering from
hemoglobinopathies as some of the most relevant disorders in the context of iron
overload (IOL) has increased enormously. Many of these patients had received
inadequate medical care in their countries of origin prior to migration,
including diagnosis and treatment of IOL. In parallel, various medical
developments and achievements took place, including the expansion of stem cell
transplant as curative therapeutic option and the introduction of gene therapy
for patients with hemoglobinopathies. Diagnostic tools to assess both liver and
heart IOL became available at more sites in Germany. Overall experience with
iron elimination therapy either as monotherapy or as combination of different
chelators increased. All these aspects were considered during revision of the
consensus-based guideline on the diagnosis and treatment of secondary IOL in
patients with congenital anemias (AWMF Reg. No. 025/029). Here, we
briefly summarize the procedure for the revision of the g...
Source: Klinische Padiatrie - Category: Pediatrics Authors: Cario, Holger Grosse, Regine Jarisch, Andrea Oevermann, Lena Puzik, Alexander Tags: Diagnostic and Treatment Recommendation Source Type: research
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